DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis
C Bernstein, H Bernstein, CM Payne… - … Research/Reviews in …, 2002 - Elsevier
Two systems are essential in humans for genome integrity, DNA repair and apoptosis. Cells
that are defective in DNA repair tend to accumulate excess DNA damage. Cells defective in
apoptosis tend to survive with excess DNA damage and thus allow DNA replication past
DNA damages, causing mutations leading to carcinogenesis. It has recently become
apparent that key proteins which contribute to cellular survival by acting in DNA repair
become executioners in the face of excess DNA damage. Five major DNA repair pathways …
that are defective in DNA repair tend to accumulate excess DNA damage. Cells defective in
apoptosis tend to survive with excess DNA damage and thus allow DNA replication past
DNA damages, causing mutations leading to carcinogenesis. It has recently become
apparent that key proteins which contribute to cellular survival by acting in DNA repair
become executioners in the face of excess DNA damage. Five major DNA repair pathways …