Clonal evolution in chronic myelogenous leukemia
J Cortes, ME O'Dwyer - Hematology/Oncology Clinics, 2004 - hemonc.theclinics.com
Chronic myelogenous leukemia (CML) is a clonal hematopoietic stem cell disorder
characterized by a specific chromosomal translocation, t (9; 22), that results in a shortened
chromosome 22, commonly referred to as the Philadelphia (Ph) chromosome [1]. The
molecular consequence of this translocation is the generation of a BCR-ABL fusion
oncogene that results in the production of a constitutively activated BCR-ABL tyrosine kinase
[2]. This kinase is capable of inducing leukemias in mice, implicating BCR-ABL as the cause …
characterized by a specific chromosomal translocation, t (9; 22), that results in a shortened
chromosome 22, commonly referred to as the Philadelphia (Ph) chromosome [1]. The
molecular consequence of this translocation is the generation of a BCR-ABL fusion
oncogene that results in the production of a constitutively activated BCR-ABL tyrosine kinase
[2]. This kinase is capable of inducing leukemias in mice, implicating BCR-ABL as the cause …