A new locus (GLC1H) for adult-onset primary open-angle glaucoma maps to the 2p15-p16 region
SP Suriyapperuma, A Child, T Desai… - Archives of …, 2007 - jamanetwork.com
Objective To map new genetic loci for adult-onset primary open-angle glaucoma (POAG) by
using families previously unlinked toGLC1A-GLC1F. Methods Initial genome scan and
subsequent saturation mapping confirmed linkage to a locus on chromosome 2p15-p16.
Forty-nine DNA samples from a single family with POAG with 113 individuals were used in
this study. The 10 affected members of this family had an average age at onset of 64 years,
moderate to high intraocular pressure, glaucomatous visual field loss, and cup-disc ratios of …
using families previously unlinked toGLC1A-GLC1F. Methods Initial genome scan and
subsequent saturation mapping confirmed linkage to a locus on chromosome 2p15-p16.
Forty-nine DNA samples from a single family with POAG with 113 individuals were used in
this study. The 10 affected members of this family had an average age at onset of 64 years,
moderate to high intraocular pressure, glaucomatous visual field loss, and cup-disc ratios of …