Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q.
MK Wirtz, JR Samples, PL Kramer, K Rust… - American journal of …, 1997 - ncbi.nlm.nih.gov
MK Wirtz, JR Samples, PL Kramer, K Rust, JR Topinka, J Yount, RD Koler, TS Acott
American journal of human genetics, 1997•ncbi.nlm.nih.govGlaucoma is the third-leading cause of blindness in the world, affecting> 13.5 million people.
Adult-onset primary open-angle glaucoma (POAG) is the most common form of glaucoma in
the United States. We present a family in which adult-onset POAG is inherited as an
autosomal dominant trait. Twelve affected family members were identified from 44 at-risk
individuals. The disease-causing gene was mapped to chromosome 3q21-24, with analysis
of recombinant haplotypes suggesting a total inclusion region of 11.1 cM between markers …
Adult-onset primary open-angle glaucoma (POAG) is the most common form of glaucoma in
the United States. We present a family in which adult-onset POAG is inherited as an
autosomal dominant trait. Twelve affected family members were identified from 44 at-risk
individuals. The disease-causing gene was mapped to chromosome 3q21-24, with analysis
of recombinant haplotypes suggesting a total inclusion region of 11.1 cM between markers …
Abstract
Glaucoma is the third-leading cause of blindness in the world, affecting> 13.5 million people. Adult-onset primary open-angle glaucoma (POAG) is the most common form of glaucoma in the United States. We present a family in which adult-onset POAG is inherited as an autosomal dominant trait. Twelve affected family members were identified from 44 at-risk individuals. The disease-causing gene was mapped to chromosome 3q21-24, with analysis of recombinant haplotypes suggesting a total inclusion region of 11.1 cM between markers D3S3637 and D3S1744. This is the first report of mapping of an adult-onset POAG gene to chromosome 3q, gene symbol GLC1C.
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