Plasma homocysteine, MTHFR gene mutation, and open-angle glaucoma

CI Clement, I Goldberg, PR Healey… - Journal of …, 2009 - journals.lww.com
Objective Elevated plasma homocysteine has been associated with an increased risk of
cardiovascular disease. The association between open-angle glaucoma and cardiovascular
disease has recently stimulated interest in the role of homocysteine in the pathogenesis of
glaucoma. Some studies report elevated plasma homocysteine in patients with
pseudoexfoliation syndrome and pseudoexfoliation glaucoma (PXFG), but have not found
this association consistently in other types of open-angle glaucoma. In this study, we have …