[HTML][HTML] Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation
S Fujii, K Ito, Y Ito, A Ochiai - Journal of Biological Chemistry, 2008 - ASBMB
Overexpression of enhancer of zeste homologue 2 (EZH2) occurs in various malignancies
and is associated with a poor prognosis, especially because of increased cancer cell
proliferation. In this study we found an inverse correlation between EZH2 and RUNX3 gene
expression in five cancer cell lines, ie gastric, breast, prostate, colon, and pancreatic cancer
cell lines. Chromatin immunoprecipitation assay showed an association between EZH2
bound to the RUNX3 gene promoter, and trimethylated histone H3 at lysine 27, and HDAC1 …
and is associated with a poor prognosis, especially because of increased cancer cell
proliferation. In this study we found an inverse correlation between EZH2 and RUNX3 gene
expression in five cancer cell lines, ie gastric, breast, prostate, colon, and pancreatic cancer
cell lines. Chromatin immunoprecipitation assay showed an association between EZH2
bound to the RUNX3 gene promoter, and trimethylated histone H3 at lysine 27, and HDAC1 …
