The efficacy of influenza vaccination in elderly individuals: a randomized double-blind placebo-controlled trial

TME Govaert, C Thijs, N Masurel, MJW Sprenger… - Jama, 1994 - jamanetwork.com
Objective.—To determine the efficacy of influenza vaccination in elderly people. Design.—
Randomized double-blind placebo-controlled trial. Setting.—Fifteen family practices in the
Netherlands during influenza season 1991-1992. Participants.—A total of 1838 subjects
aged 60 years or older, not known as belonging to those high-risk groups in which
vaccination was previously given. Intervention.—Purified split-virion vaccine containing
A/Singapore/6/86 (H1N1), A/Beijing/353/89 (H3N2), B/Beijing/1/87, and B/Panama/45/90 …