Organic anion-binding protein in rat liver: drug induction and its physiologic consequence
H Reyes, AJ Levi, Z Gatmaitan… - Proceedings of the …, 1969 - National Acad Sciences
H Reyes, AJ Levi, Z Gatmaitan, IM Arias
Proceedings of the National Academy of Sciences, 1969•National Acad SciencesThe administration of phenobarbital to rats enhanced hepatic uptake of an organic anion,
bromsulphalein, in vivo and simultaneously increased the amount of Y, a hepatic
cytoplasmic organic anion-binding protein. This study supports the postulate that Y is a
major determinant in the selective hepatic uptake of certain organic anions from plasma.
Induction of Y may contribute to the enhanced hepatic uptake and metabolism of various
organic anions (drugs, hormones, etc.) produced by phenobarbital and other agents.
bromsulphalein, in vivo and simultaneously increased the amount of Y, a hepatic
cytoplasmic organic anion-binding protein. This study supports the postulate that Y is a
major determinant in the selective hepatic uptake of certain organic anions from plasma.
Induction of Y may contribute to the enhanced hepatic uptake and metabolism of various
organic anions (drugs, hormones, etc.) produced by phenobarbital and other agents.
The administration of phenobarbital to rats enhanced hepatic uptake of an organic anion, bromsulphalein, in vivo and simultaneously increased the amount of Y, a hepatic cytoplasmic organic anion-binding protein. This study supports the postulate that Y is a major determinant in the selective hepatic uptake of certain organic anions from plasma. Induction of Y may contribute to the enhanced hepatic uptake and metabolism of various organic anions (drugs, hormones, etc.) produced by phenobarbital and other agents.
National Acad Sciences