The pathologic effects of intravenously administered soluble antigen-antibody complexes: II. Acute glomerulonephritis in rats
B Benacerraf, JL Potter, RT McCluskey… - The Journal of …, 1960 - ncbi.nlm.nih.gov
B Benacerraf, JL Potter, RT McCluskey, F Miller
The Journal of experimental medicine, 1960•ncbi.nlm.nih.govThe intravenous administration to rats of soluble antigen-antibody complexes in antigen
excess resulted in acute glomerulonephritis. This occurred with both rabbit antiovalbumin
and rabbit anti-BSA systems. The rats so treated regularly showed proteinuria and elevation
of blood urea nitrogen. These findings are compared with those reported in rats injected with
anti-kidney serum.
excess resulted in acute glomerulonephritis. This occurred with both rabbit antiovalbumin
and rabbit anti-BSA systems. The rats so treated regularly showed proteinuria and elevation
of blood urea nitrogen. These findings are compared with those reported in rats injected with
anti-kidney serum.
Abstract
The intravenous administration to rats of soluble antigen-antibody complexes in antigen excess resulted in acute glomerulonephritis. This occurred with both rabbit antiovalbumin and rabbit anti-BSA systems. The rats so treated regularly showed proteinuria and elevation of blood urea nitrogen. These findings are compared with those reported in rats injected with anti-kidney serum.
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