Autoantibody to centromere (kinetochore) in scleroderma sera.
Y Moroi, C Peebles, MJ Fritzler… - Proceedings of the …, 1980 - National Acad Sciences
Y Moroi, C Peebles, MJ Fritzler, J Steigerwald, EM Tan
Proceedings of the National Academy of Sciences, 1980•National Acad SciencesSera from patients with scleroderma contained several autoantibodies to nuclear antigens
which were distinguished by different patterns of nuclear immunofluorescence staining. One
of these autoantibodies reacted with centromeric regions of chromosomes. In chromosome
spreads, the staining appeared as two small spheres at the centromere, resembling
kinetochores. The antigenic determinant appeared to be a protein or polypeptide tightly
bound to DNA. The autoantibody was reactive with centromeres of cells derived from …
which were distinguished by different patterns of nuclear immunofluorescence staining. One
of these autoantibodies reacted with centromeric regions of chromosomes. In chromosome
spreads, the staining appeared as two small spheres at the centromere, resembling
kinetochores. The antigenic determinant appeared to be a protein or polypeptide tightly
bound to DNA. The autoantibody was reactive with centromeres of cells derived from …
Sera from patients with scleroderma contained several autoantibodies to nuclear antigens which were distinguished by different patterns of nuclear immunofluorescence staining. One of these autoantibodies reacted with centromeric regions of chromosomes. In chromosome spreads, the staining appeared as two small spheres at the centromere, resembling kinetochores. The antigenic determinant appeared to be a protein or polypeptide tightly bound to DNA. The autoantibody was reactive with centromeres of cells derived from humans, mice, and Chinese hamsters. The autoantibody was present in high frequency in the calcinosis/Raynaud's phenomenon/esophageal dysmotility/sclerodactyly/telangiectasia variant (CREST) of scleroderma.
National Acad Sciences
