[HTML][HTML] Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II
HJ Durrington, PD Upton, S Hoer, J Boname… - Journal of biological …, 2010 - ASBMB
Bone morphogenetic proteins (BMPs) are critically involved in early development and cell
differentiation. In humans, dysfunction of the bone morphogenetic protein type II receptor
(BMPR-II) is associated with pulmonary arterial hypertension (PAH) and neoplasia. The
ability of Kaposi sarcoma-associated herpesvirus (KSHV), the etiologic agent of Kaposi
sarcoma and primary effusion lymphoma, to down-regulate cell surface receptor expression
is well documented. Here we show that KSHV infection reduces cell surface BMPR-II. We …
differentiation. In humans, dysfunction of the bone morphogenetic protein type II receptor
(BMPR-II) is associated with pulmonary arterial hypertension (PAH) and neoplasia. The
ability of Kaposi sarcoma-associated herpesvirus (KSHV), the etiologic agent of Kaposi
sarcoma and primary effusion lymphoma, to down-regulate cell surface receptor expression
is well documented. Here we show that KSHV infection reduces cell surface BMPR-II. We …
