[HTML][HTML] Mammalian Ste20-like Kinase (Mst2) Indirectly Supports Raf-1/ERK Pathway Activity via Maintenance of Protein Phosphatase-2A Catalytic Subunit Levels …
GK Kilili, JM Kyriakis - Journal of biological chemistry, 2010 - ASBMB
Many tumor suppressor proteins act to blunt the effects of mitogenic signaling pathways.
Loss of function mutations in the merlin tumor suppressor underlie neurofibromatosis type 2
(NF2), a familial autosomal dominant cancer syndrome. Studies of Drosophila suggest that
Hippo (hpo) is required for inhibition of cell proliferation mediated by dMer, the orthologue of
human merlin. Mammalian sterile 20-like kinase-2 (Mst2) is a mammalian Hpo orthologue,
and numerous studies implicate Mst2 as a tumor suppressor. Mst2 is negatively regulated by …
Loss of function mutations in the merlin tumor suppressor underlie neurofibromatosis type 2
(NF2), a familial autosomal dominant cancer syndrome. Studies of Drosophila suggest that
Hippo (hpo) is required for inhibition of cell proliferation mediated by dMer, the orthologue of
human merlin. Mammalian sterile 20-like kinase-2 (Mst2) is a mammalian Hpo orthologue,
and numerous studies implicate Mst2 as a tumor suppressor. Mst2 is negatively regulated by …
