[HTML][HTML] Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin
Y Wang, F Shibasaki, K Mizuno - Journal of Biological Chemistry, 2005 - ASBMB
Cofilin, an essential regulator of actin filament dynamics, is inactivated by phosphorylation at
Ser-3 and reactivated by dephosphorylation. Although cofilin undergoes dephosphorylation
in response to extracellular stimuli that elevate intracellular Ca 2+ concentrations, signaling
mechanisms mediating Ca 2+-induced cofilin dephosphorylation have remained unknown.
We investigated the role of Slingshot (SSH) 1L, a member of a SSH family of protein
phosphatases, in mediating Ca 2+-induced cofilin dephosphorylation. The Ca 2+ ionophore …
Ser-3 and reactivated by dephosphorylation. Although cofilin undergoes dephosphorylation
in response to extracellular stimuli that elevate intracellular Ca 2+ concentrations, signaling
mechanisms mediating Ca 2+-induced cofilin dephosphorylation have remained unknown.
We investigated the role of Slingshot (SSH) 1L, a member of a SSH family of protein
phosphatases, in mediating Ca 2+-induced cofilin dephosphorylation. The Ca 2+ ionophore …