Signaling-mediated bacterial persister formation
Nature chemical biology, 2012•nature.com
Here we show that bacterial communication through indole signaling induces persistence, a
phenomenon in which a subset of an isogenic bacterial population tolerates antibiotic
treatment. We monitor indole-induced persister formation using microfluidics and identify the
role of oxidative-stress and phage-shock pathways in this phenomenon. We propose a
model in which indole signaling'inoculates'a bacterial subpopulation against antibiotics by
activating stress responses, leading to persister formation.
phenomenon in which a subset of an isogenic bacterial population tolerates antibiotic
treatment. We monitor indole-induced persister formation using microfluidics and identify the
role of oxidative-stress and phage-shock pathways in this phenomenon. We propose a
model in which indole signaling'inoculates'a bacterial subpopulation against antibiotics by
activating stress responses, leading to persister formation.
Abstract
Here we show that bacterial communication through indole signaling induces persistence, a phenomenon in which a subset of an isogenic bacterial population tolerates antibiotic treatment. We monitor indole-induced persister formation using microfluidics and identify the role of oxidative-stress and phage-shock pathways in this phenomenon. We propose a model in which indole signaling 'inoculates' a bacterial subpopulation against antibiotics by activating stress responses, leading to persister formation.
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