Effect of interferon gamma on infection-related death in patients with severe injuries: a randomized, double-blind, placebo-controlled trial
DJ Dries, GJ Jurkovich, RV Maier… - Archives of …, 1994 - jamanetwork.com
Objective: To assess the efficacy of interferon gamma in reducing infection and death in
patients sustaining severe injury. Design: Multicenter, randomized, double-blind, placebo-
controlled trial with observation for 60 days and until discharge for patients with major
infection on day 60. Setting: Nine university-affiliated level 1 trauma centers. Patients: Four
hundred sixteen patients with severe injuries, assessed by Injury Severity Score and degree
of contamination. Intervention: Recombinant human interferon gamma, 100 μg, was …
patients sustaining severe injury. Design: Multicenter, randomized, double-blind, placebo-
controlled trial with observation for 60 days and until discharge for patients with major
infection on day 60. Setting: Nine university-affiliated level 1 trauma centers. Patients: Four
hundred sixteen patients with severe injuries, assessed by Injury Severity Score and degree
of contamination. Intervention: Recombinant human interferon gamma, 100 μg, was …
