[HTML][HTML] Erosion of transplantation tolerance after infection
JS Young, MD Daniels, ML Miller, T Wang… - American Journal of …, 2017 - Elsevier
Recent clinical studies suggest that operational allograft tolerance can be persistent, but
long-term surviving allografts can be rejected in a subset of patients, sometimes after
episodes of infection. In this study, we examined the impact of Listeria monocytogenes (Lm)
infection on the quality of tolerance in a mouse model of heart allograft transplantation. Lm
infection induced full rejection in 40% of tolerant recipients, with the remaining experiencing
a rejection crisis or no palpable change in their allografts. In the surviving allografts on day 8 …
long-term surviving allografts can be rejected in a subset of patients, sometimes after
episodes of infection. In this study, we examined the impact of Listeria monocytogenes (Lm)
infection on the quality of tolerance in a mouse model of heart allograft transplantation. Lm
infection induced full rejection in 40% of tolerant recipients, with the remaining experiencing
a rejection crisis or no palpable change in their allografts. In the surviving allografts on day 8 …