[HTML][HTML] Treg-centric view of immunosuppressive drugs in transplantation: a balancing act
G Camirand, LV Riella - American Journal of Transplantation, 2017 - Elsevier
Regulatory CD4+ Foxp3+ T cells (Tregs) are critical in controlling immunity and tolerance.
Thus, preserving Treg numbers and function in transplanted patients is essential for the
successful minimization of maintenance immunosuppression. Multiple cellular signals
control the development, differentiation, and function of Tregs. Many of these signals are
shared with conventional Foxp3− T cells (Tconv) and are targeted by immunosuppressive
drugs, negatively affecting both Tregs and Tconv. Because intracellular signals vary in …
Thus, preserving Treg numbers and function in transplanted patients is essential for the
successful minimization of maintenance immunosuppression. Multiple cellular signals
control the development, differentiation, and function of Tregs. Many of these signals are
shared with conventional Foxp3− T cells (Tconv) and are targeted by immunosuppressive
drugs, negatively affecting both Tregs and Tconv. Because intracellular signals vary in …