[HTML][HTML] Acquisition of C3d‐binding activity by de novo donor‐specific HLA antibodies correlates with graft loss in nonsensitized pediatric kidney recipients
P Comoli, M Cioni, A Tagliamacco, G Quartuccio… - American Journal of …, 2016 - Elsevier
Alloantibody‐mediated graft injury is a major cause of kidney dysfunction and loss. The
complement‐binding ability of de novo donor‐specific antibodies (dnDSAs) has been
suggested as a prognostic tool to stratify patients for clinical risk. In this study, we analyzed
posttransplant kinetics of complement‐fixing dnDSAs and their role in antibody‐mediated
rejection development and graft loss. A total of 114 pediatric nonsensitized recipients of first
kidney allograft were periodically monitored for dnDSAs using flow bead assays, followed by …
complement‐binding ability of de novo donor‐specific antibodies (dnDSAs) has been
suggested as a prognostic tool to stratify patients for clinical risk. In this study, we analyzed
posttransplant kinetics of complement‐fixing dnDSAs and their role in antibody‐mediated
rejection development and graft loss. A total of 114 pediatric nonsensitized recipients of first
kidney allograft were periodically monitored for dnDSAs using flow bead assays, followed by …