Proteases involved in the metabolism of angiotensin II, bradykinin, calcitonin gene-related peptide (CGRP), and neuropeptide Y by vascular smooth muscle cells
R Mentlein, T Roos - Peptides, 1996 - Elsevier
To understand the regulation of the vasoactive peptides bradykinin, angiotensin II, calcitonin
gene-related peptide (CGRP), and neuropeptide Y (NPY), their proteolytic catabolism by
cultured rat aortic vascular smooth muscle cells and A7r5 cells was investigated.
Endopeptidase-24.11 (EC 3.4. 24.11, CD 10) was responsible for the final inactivation of
bradykinin, angiotensin II, and CGRP, but not of NPY, which was degraded by a different
metallo-endopeptidase. Exopeptidases, namely the aminopeptidases A (EC 3.4. 11.7), N …
gene-related peptide (CGRP), and neuropeptide Y (NPY), their proteolytic catabolism by
cultured rat aortic vascular smooth muscle cells and A7r5 cells was investigated.
Endopeptidase-24.11 (EC 3.4. 24.11, CD 10) was responsible for the final inactivation of
bradykinin, angiotensin II, and CGRP, but not of NPY, which was degraded by a different
metallo-endopeptidase. Exopeptidases, namely the aminopeptidases A (EC 3.4. 11.7), N …
