[HTML][HTML] Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor
MP Arrate, JM Rodriguez, TM Tran, TA Brock… - Journal of Biological …, 2001 - ASBMB
We have identified a third member of the junctional adhesion molecule (JAM) family. At the
protein level JAM3 displays 36 and 32% identity to JAM2 and JAM1, respectively. The
coding region is distributed over 9 exons and maps to chromosome 11q25. The gene shows
widespread tissue expression with higher levels apparent in the kidney, brain, and placenta.
At the cellular level we show expression of JAM3 transcript within endothelial cells. Our
major finding is that JAM3 and JAM2 are binding partners. Thus, JAM3 ectodomain binds …
protein level JAM3 displays 36 and 32% identity to JAM2 and JAM1, respectively. The
coding region is distributed over 9 exons and maps to chromosome 11q25. The gene shows
widespread tissue expression with higher levels apparent in the kidney, brain, and placenta.
At the cellular level we show expression of JAM3 transcript within endothelial cells. Our
major finding is that JAM3 and JAM2 are binding partners. Thus, JAM3 ectodomain binds …