N-Cadherin and Tie2 positive CD34+ CD38− CD123+ leukemic stem cell populations can develop acute myeloid leukemia more effectively in NOD/SCID mice
S Qiu, Y Jia, H Xing, T Yu, J Yu, P Yu, K Tang, Z Tian… - Leukemia research, 2014 - Elsevier
Emerging studies suggest that the population of malignant cells found in human acute
myelogenous leukemia (AML) arises from a rare population of leukemic stem cells (LSCs). A
lot of investigators have reported the identification of cell surface markers, such as CD123.
Here, we report the identification of N-cadherin and Tie2 as LSCs markers. Inoculation of
CD34+ CD38− CD123+ N-cadherin+ and CD34+ CD38− CD123+ Tie2+ population can
induce leukemia in NOD/SCID mice. The leukemic blast cells from the primary leukemic …
myelogenous leukemia (AML) arises from a rare population of leukemic stem cells (LSCs). A
lot of investigators have reported the identification of cell surface markers, such as CD123.
Here, we report the identification of N-cadherin and Tie2 as LSCs markers. Inoculation of
CD34+ CD38− CD123+ N-cadherin+ and CD34+ CD38− CD123+ Tie2+ population can
induce leukemia in NOD/SCID mice. The leukemic blast cells from the primary leukemic …