Sphingosine kinase 2 deficiency attenuates kidney fibrosis via IFN-γ
A Bajwa, L Huang, E Kurmaeva, H Ye… - Journal of the …, 2017 - journals.lww.com
Maladaptive repair after AKI may lead to progressive fibrosis and decline in kidney function.
Sphingosine 1-phosphate has an important role in kidney injury and pleiotropic effects in
fibrosis. We investigated the involvement of sphingosine kinase 1 and 2 (SphK1 and
SphK2), which phosphorylate sphingosine to produce sphingosine 1-phosphate, in kidney
fibrosis induced by folic acid (FA) or unilateral ischemia-reperfusion injury. Analysis of
Masson trichrome staining and fibrotic marker protein and mRNA expression 14 days after …
Sphingosine 1-phosphate has an important role in kidney injury and pleiotropic effects in
fibrosis. We investigated the involvement of sphingosine kinase 1 and 2 (SphK1 and
SphK2), which phosphorylate sphingosine to produce sphingosine 1-phosphate, in kidney
fibrosis induced by folic acid (FA) or unilateral ischemia-reperfusion injury. Analysis of
Masson trichrome staining and fibrotic marker protein and mRNA expression 14 days after …