Intracellular calcium release channels: an update
G Santulli, R Nakashima, Q Yuan… - The Journal of …, 2017 - Wiley Online Library
The Journal of physiology, 2017•Wiley Online Library
Ryanodine receptors (RyRs) and inositol 1, 4, 5‐trisphosphate receptors (IP3Rs) are
calcium (Ca2+) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we
summarize the latest advances in the field, describing the recently discovered mechanistic
roles of intracellular Ca2+ release channels in the regulation of mitochondrial fitness and
endothelial function, providing novel therapeutic options for the treatment of heart failure,
hypertension, and diabetes mellitus.
calcium (Ca2+) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we
summarize the latest advances in the field, describing the recently discovered mechanistic
roles of intracellular Ca2+ release channels in the regulation of mitochondrial fitness and
endothelial function, providing novel therapeutic options for the treatment of heart failure,
hypertension, and diabetes mellitus.
Abstract
Ryanodine receptors (RyRs) and inositol 1,4,5‐trisphosphate receptors (IP3Rs) are calcium (Ca2+) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we summarize the latest advances in the field, describing the recently discovered mechanistic roles of intracellular Ca2+ release channels in the regulation of mitochondrial fitness and endothelial function, providing novel therapeutic options for the treatment of heart failure, hypertension, and diabetes mellitus.
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