[HTML][HTML] Protein kinase A and two phosphatases are components of the inositol 1, 4, 5-trisphosphate receptor macromolecular signaling complex
N DeSouza, S Reiken, K Ondrias, Y Yang… - Journal of Biological …, 2002 - ASBMB
The inositol 1, 4, 5-trisphosphate receptor (IP3R) is a ubiquitously expressed intracellular
calcium (Ca 2+) release channel on the endoplasmic reticulum. IP3Rs play key roles in
controlling Ca 2+ signals that activate numerous cellular functions including T cell activation,
neurotransmitter release, oocyte fertilization and apoptosis. There are three forms of IP3R,
all of which are ligand-gated channels activated by the second messenger inositol 1, 4, 5-
trisphosphate. Channel function is modulated via cross-talk with other signaling pathways …
calcium (Ca 2+) release channel on the endoplasmic reticulum. IP3Rs play key roles in
controlling Ca 2+ signals that activate numerous cellular functions including T cell activation,
neurotransmitter release, oocyte fertilization and apoptosis. There are three forms of IP3R,
all of which are ligand-gated channels activated by the second messenger inositol 1, 4, 5-
trisphosphate. Channel function is modulated via cross-talk with other signaling pathways …
