[HTML][HTML] Mechanism of endogenous regulation of the type I interferon response by suppressor of IκB kinase ϵ (SIKE), a novel substrate of TANK-binding kinase 1 …
JD Marion, CF Roberts, RJ Call, JL Forbes… - Journal of Biological …, 2013 - ASBMB
TANK-binding kinase 1 (TBK1) serves as a key convergence point in multiple innate
immune signaling pathways. In response to receptor-mediated pathogen detection, TBK1
phosphorylation promotes production of pro-inflammatory cytokines and type I interferons.
Increasingly, TBK1 dysregulation has been linked to autoimmune disorders and cancers,
heightening the need to understand the regulatory controls of TBK1 activity. Here, we
describe the mechanism by which suppressor of IKKϵ (SIKE) inhibits TBK1-mediated …
immune signaling pathways. In response to receptor-mediated pathogen detection, TBK1
phosphorylation promotes production of pro-inflammatory cytokines and type I interferons.
Increasingly, TBK1 dysregulation has been linked to autoimmune disorders and cancers,
heightening the need to understand the regulatory controls of TBK1 activity. Here, we
describe the mechanism by which suppressor of IKKϵ (SIKE) inhibits TBK1-mediated …
