Sestrins are a family of stress-responsive genes that have evolved to attenuate damage
induced by stress caused to the cell. By virtue of their antioxidant activity, protein products of
Sestrin genes prevent the accumulation of reactive oxygen species within the cell, thereby
attenuating the detrimental effects of oxidative stress. In parallel, Sestrins participate in
several signaling pathways that control the activity of the target of rapamycin protein kinase
(TOR). TOR is a crucial sensor of intracellular and extracellular conditions that promotes cell …