[HTML][HTML] Patients with autoimmune polyendocrine syndrome type 1 have an increased susceptibility to severe herpesvirus infections
I Hetemäki, S Laakso, H Välimaa, I Kleino… - Clinical …, 2021 - Elsevier
Almost all patients with autoimmune polyendocrine syndrome type 1 (APS-1) have
neutralizing antibodies against type 1 interferons (IFN), important mediators of antiviral
defense. Recently, neutralizing anti-IFN antibodies were shown to be a risk factor of severe
COVID-19. Here we show in a cohort of 44 patients with APS-1 that higher titers of
neutralizing anti-IFNα4 antibodies are associated with a higher and earlier incidence of VZV
reactivation (herpes zoster). The patients also present with uncommonly severe clinical …
neutralizing antibodies against type 1 interferons (IFN), important mediators of antiviral
defense. Recently, neutralizing anti-IFN antibodies were shown to be a risk factor of severe
COVID-19. Here we show in a cohort of 44 patients with APS-1 that higher titers of
neutralizing anti-IFNα4 antibodies are associated with a higher and earlier incidence of VZV
reactivation (herpes zoster). The patients also present with uncommonly severe clinical …