Anticytokine autoantibodies in a patient with a heterozygous NFKB2 mutation
KA Ramakrishnan, W Rae… - Journal of Allergy and …, 2018 - jacionline.org
To the Editor: Germline heterozygous NFKB2 variants that result in an unprocessable NF-
kB2 (nuclear factor-kappa-B) p100 subunit have been identified as a cause of primary
immunodeficiency. 1 Patients often present with clinical and immunological features
consistent with common variable immunodeficiency (CVID); however, additional defects in T
and natural killer cells have been reported, widening the immunological phenotype.
Multisystem autoimmunity is also frequently present in patients with damaging NFKB2 …
kB2 (nuclear factor-kappa-B) p100 subunit have been identified as a cause of primary
immunodeficiency. 1 Patients often present with clinical and immunological features
consistent with common variable immunodeficiency (CVID); however, additional defects in T
and natural killer cells have been reported, widening the immunological phenotype.
Multisystem autoimmunity is also frequently present in patients with damaging NFKB2 …