Temporal dynamics of anti–type 1 interferon autoantibodies in patients with coronavirus disease 2019
Clinical Infectious Diseases, 2022•academic.oup.com
Binding levels and neutralization activity of anti–type 1 interferon autoantibodies peaked
during acute coronavirus disease 2019 and markedly decreased thereafter. Most patients
maintained some ability to neutralize type 1 interferon into convalescence despite lower
levels of binding immunoglobulin G. Identifying these autoantibodies in healthy individuals
before the development of critical viral disease may be challenging.
during acute coronavirus disease 2019 and markedly decreased thereafter. Most patients
maintained some ability to neutralize type 1 interferon into convalescence despite lower
levels of binding immunoglobulin G. Identifying these autoantibodies in healthy individuals
before the development of critical viral disease may be challenging.
Abstract
Binding levels and neutralization activity of anti–type 1 interferon autoantibodies peaked during acute coronavirus disease 2019 and markedly decreased thereafter. Most patients maintained some ability to neutralize type 1 interferon into convalescence despite lower levels of binding immunoglobulin G. Identifying these autoantibodies in healthy individuals before the development of critical viral disease may be challenging.
Oxford University Press