Null IFNAR1 and IFNAR2 alleles are surprisingly common in the Pacific and Arctic
I Meyts - 2022 - rupress.org
2022•rupress.org
In this issue of JEM, Bastard et al.(2022. J. Exp. Med. https://doi. org/10.1084/jem.
20220028) show that a loss-of-function IFNAR1 allele is common in western Polynesians,
while Duncan et al.(2022. J. Exp. Med. https://doi. org/10.1084/jem. 20212427) report that a
loss-of-function IFNAR2 allele is common in Inuits. Homozygotes lack type I IFN immunity
but are selectively vulnerable to influenza, COVID-19 pneumonia, and complications of live-
attenuated viral vaccines.
20220028) show that a loss-of-function IFNAR1 allele is common in western Polynesians,
while Duncan et al.(2022. J. Exp. Med. https://doi. org/10.1084/jem. 20212427) report that a
loss-of-function IFNAR2 allele is common in Inuits. Homozygotes lack type I IFN immunity
but are selectively vulnerable to influenza, COVID-19 pneumonia, and complications of live-
attenuated viral vaccines.
In this issue of JEM, Bastard et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20220028) show that a loss-of-function IFNAR1 allele is common in western Polynesians, while Duncan et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20212427) report that a loss-of-function IFNAR2 allele is common in Inuits. Homozygotes lack type I IFN immunity but are selectively vulnerable to influenza, COVID-19 pneumonia, and complications of live-attenuated viral vaccines.
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