Expression of myosin heavy chain isoforms in Duchenne muscular dystrophy patients and carriers
JF Marini, F Pons, J Leger, N Loffreda, M Anoal… - Neuromuscular …, 1991 - Elsevier
The expression of MHC isoforms in the skeletal muscles of nine patients with Duchenne
muscular dystrophy (DMD)(from 2.5 to 15 yr of age) and three DMD carriers was studied
using different specific anti-MHC MAbs. We also analyzed muscle fiber size and fiber
reactivity with acridine orange and/or with a surface antigen marker. One-quarter of all fibers
of DMD patients, or less with age, were of normal size and contained only adult slow MHC.
Half of the muscle fibers contained adult and developmental MHCs. Only half of these fibers …
muscular dystrophy (DMD)(from 2.5 to 15 yr of age) and three DMD carriers was studied
using different specific anti-MHC MAbs. We also analyzed muscle fiber size and fiber
reactivity with acridine orange and/or with a surface antigen marker. One-quarter of all fibers
of DMD patients, or less with age, were of normal size and contained only adult slow MHC.
Half of the muscle fibers contained adult and developmental MHCs. Only half of these fibers …
