Measuring progressive neurological disability in a mouse model of multiple sclerosis
F Gilli, DB Royce, AR Pachner - JoVE (Journal of Visualized Experiments), 2016 - jove.com
After intracerebral infection with the Theiler's Murine Encephalomyelitis Virus (TMEV),
susceptible SJL mice develop a chronic-progressive demyelinating disease, with clinical
features similar to the progressive forms of multiple sclerosis (MS). The mice show
progressive disability with loss of motor and sensory functions, which can be assessed with
multiple apparatuses and protocols. Among them, the Rotarod performance test is a very
common behavioral test, its advantage being that it provides objective measurements, but it …
susceptible SJL mice develop a chronic-progressive demyelinating disease, with clinical
features similar to the progressive forms of multiple sclerosis (MS). The mice show
progressive disability with loss of motor and sensory functions, which can be assessed with
multiple apparatuses and protocols. Among them, the Rotarod performance test is a very
common behavioral test, its advantage being that it provides objective measurements, but it …
