[HTML][HTML] Dopamine-derived quinones affect the structure of the redox sensor DJ-1 through modifications at Cys-106 and Cys-53
The physiological role of DJ-1, a protein involved in familial Parkinson disease is still
controversial. One of the hypotheses proposed indicates a sensor role for oxidative stress,
through oxidation of a conserved cysteine residue (Cys-106). The association of DJ-1
mutations with Parkinson disease suggests a loss of function, specific to dopaminergic
neurons. Under oxidative conditions, highly reactive dopamine quinones (DAQs) can be
produced, which can modify cysteine residues. In cellular models, DJ-1 was found …
controversial. One of the hypotheses proposed indicates a sensor role for oxidative stress,
through oxidation of a conserved cysteine residue (Cys-106). The association of DJ-1
mutations with Parkinson disease suggests a loss of function, specific to dopaminergic
neurons. Under oxidative conditions, highly reactive dopamine quinones (DAQs) can be
produced, which can modify cysteine residues. In cellular models, DJ-1 was found …