[HTML][HTML] Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes
T Tsutsui, R Fukasawa, K Shinmyouzu… - Journal of Biological …, 2013 - ASBMB
The Mediator complex (Mediator) plays pivotal roles in activating transcription by RNA
polymerase II, but relatively little is known about its roles in repression. Here, we identified
the histone arginine methyltransferase PRMT5 and WD repeat protein 77/methylosome
protein 50 (WDR77/MEP50) as Mediator cyclin-dependent kinase (CDK)-interacting proteins
and studied the roles of PRMT5 in the transcriptional regulation of CCAAT enhancer-binding
protein (C/EBP) β target genes. First, we purified CDK8-and CDK19-containing complexes …
polymerase II, but relatively little is known about its roles in repression. Here, we identified
the histone arginine methyltransferase PRMT5 and WD repeat protein 77/methylosome
protein 50 (WDR77/MEP50) as Mediator cyclin-dependent kinase (CDK)-interacting proteins
and studied the roles of PRMT5 in the transcriptional regulation of CCAAT enhancer-binding
protein (C/EBP) β target genes. First, we purified CDK8-and CDK19-containing complexes …