Neutrophils in host defense, healing, and hypersensitivity: Dynamic cells within a dynamic host

M Siwicki, P Kubes - Journal of Allergy and Clinical Immunology, 2023 - Elsevier
Neutrophils are cells of the innate immune system that are extremely abundant in vivo and
respond quickly to infection, injury, and inflammation. Their constant circulation throughout
the body makes them some of the first responders to infection, and indeed they play a critical
role in host defense against bacterial and fungal pathogens. It is now appreciated that
neutrophils also play an important role in tissue healing after injury. Their short life cycle,
rapid response kinetics, and vast numbers make neutrophils a highly dynamic and …