[HTML][HTML] Vaccine-induced antigen-specific regulatory T cells attenuate the antiviral immunity against acute influenza virus infection
PH Lin, WI Wong, YL Wang, MP Hsieh, C Lu… - Mucosal …, 2018 - Elsevier
Peptide-based T cell vaccines targeting the conserved epitopes of influenza virus can
provide cross-protection against distantly related strains, but they are generally not
immunogenic. Foreign antigen-specific regulatory T (Treg) cells are induced under
subimmunogenic conditions peripherally, although their development and role in vaccine-
mediated antiviral immunity is unclear. Here, we demonstrated primary vaccination with
peptides alone significantly induced antigen-specific Foxp3+ Treg cells, which were further …
provide cross-protection against distantly related strains, but they are generally not
immunogenic. Foreign antigen-specific regulatory T (Treg) cells are induced under
subimmunogenic conditions peripherally, although their development and role in vaccine-
mediated antiviral immunity is unclear. Here, we demonstrated primary vaccination with
peptides alone significantly induced antigen-specific Foxp3+ Treg cells, which were further …