Improvement of bleomycin-induced pulmonary hypertension and pulmonary fibrosis by the endothelin receptor antagonist Bosentan
S Schroll, M Arzt, D Sebah, M Nüchterlein… - Respiratory physiology …, 2010 - Elsevier
RATIONALE: There is evidence that endothelin plays a key role in the development of
pulmonary hypertension (PH) in pulmonary fibrosis (PF). However, the functional
consequence of the unselective endothelin receptor antagonist Bosentan in PH and PF has
not yet been studied. Therefore, we investigated the effects of Bosentan on the development
of PH in the model of Bleomycin-induced PF in rats. METHODS: Adult male Wistar rats were
randomly assigned to the following groups: untreated animals (controls), Bleomycin-induced …
pulmonary hypertension (PH) in pulmonary fibrosis (PF). However, the functional
consequence of the unselective endothelin receptor antagonist Bosentan in PH and PF has
not yet been studied. Therefore, we investigated the effects of Bosentan on the development
of PH in the model of Bleomycin-induced PF in rats. METHODS: Adult male Wistar rats were
randomly assigned to the following groups: untreated animals (controls), Bleomycin-induced …