Inflammatory mechanisms in patients with chronic obstructive pulmonary disease
PJ Barnes - Journal of Allergy and Clinical Immunology, 2016 - Elsevier
Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation
affecting predominantly the lung parenchyma and peripheral airways that results in largely
irreversible and progressive airflow limitation. This inflammation is characterized by
increased numbers of alveolar macrophages, neutrophils, T lymphocytes (predominantly TC
1, TH 1, and TH 17 cells), and innate lymphoid cells recruited from the circulation. These
cells and structural cells, including epithelial and endothelial cells and fibroblasts, secrete a …
affecting predominantly the lung parenchyma and peripheral airways that results in largely
irreversible and progressive airflow limitation. This inflammation is characterized by
increased numbers of alveolar macrophages, neutrophils, T lymphocytes (predominantly TC
1, TH 1, and TH 17 cells), and innate lymphoid cells recruited from the circulation. These
cells and structural cells, including epithelial and endothelial cells and fibroblasts, secrete a …