3D intestinal organoids in metabolic research: virtual reality in a dish
A Tsakmaki, PF Pedro, GA Bewick - Current Opinion in Pharmacology, 2017 - Elsevier
Highlights•Organoids can be generated from adult stem cells or iPSCs.•Organoids exhibit all
intestinal epithelial cell types including functional EECs.•Organoids can be generated from
patient specific biopsies.•Organoids are amenable to numerous molecular and genetic
techniques.•Current organoid usage in transdifferentiation, cell fate and function of
EECs.The advent of near physiological organoid technology has produced a step change in
our understanding of stem cells and has provided the research community with a powerful …
intestinal epithelial cell types including functional EECs.•Organoids can be generated from
patient specific biopsies.•Organoids are amenable to numerous molecular and genetic
techniques.•Current organoid usage in transdifferentiation, cell fate and function of
EECs.The advent of near physiological organoid technology has produced a step change in
our understanding of stem cells and has provided the research community with a powerful …
