Despite the great progress in translational research concerning skin wound healing in the
last few decades, no animal model fully predicts all clinical outcomes. The mouse is the most
commonly used model, as it is easy to maintain and standardize, and is economically
accessible. However, differences between murine and human skin repair, such as the
contraction promoted by panniculus carnosus and the role of specific niches of skin stem
cells, make it difficult to bridge the gap between preclinical and clinical studies. Therefore …