[HTML][HTML] The JAK/STAT signaling pathway: from bench to clinic
X Hu, J Li, M Fu, X Zhao, W Wang - Signal transduction and targeted …, 2021 - nature.com
X Hu, J Li, M Fu, X Zhao, W Wang
Signal transduction and targeted therapy, 2021•nature.comThe Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular
processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling
module and induces the expression of various critical mediators of cancer and inflammation.
Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with
various cancers and autoimmune diseases. In this review, we discuss the current knowledge …
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular
processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling
module and induces the expression of various critical mediators of cancer and inflammation.
Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with
various cancers and autoimmune diseases. In this review, we discuss the current knowledge …
Abstract
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation. Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases. In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway. Moreover, we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases.
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