Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma: a randomized clinical …
R Stupp, S Taillibert, A Kanner, W Read, DM Steinberg… - Jama, 2017 - jamanetwork.com
Importance Tumor-treating fields (TTFields) is an antimitotic treatment modality that
interferes with glioblastoma cell division and organelle assembly by delivering low-intensity
alternating electric fields to the tumor. Objective To investigate whether TTFields improves
progression-free and overall survival of patients with glioblastoma, a fatal disease that
commonly recurs at the initial tumor site or in the central nervous system. Design, Setting,
and Participants In this randomized, open-label trial, 695 patients with glioblastoma whose …
interferes with glioblastoma cell division and organelle assembly by delivering low-intensity
alternating electric fields to the tumor. Objective To investigate whether TTFields improves
progression-free and overall survival of patients with glioblastoma, a fatal disease that
commonly recurs at the initial tumor site or in the central nervous system. Design, Setting,
and Participants In this randomized, open-label trial, 695 patients with glioblastoma whose …