Background & Aims Alcoholic hepatitis (AH) is a life-threatening disease with limited
therapeutic options, as the molecular mechanisms leading to death are not well understood.
This study evaluates the Hippo/Yes-associated protein (YAP) pathway which has been
shown to play a role in liver regeneration. Method The Hippo/YAP pathway was dissected in
explants of patients transplanted for AH or alcohol-related cirrhosis and in control livers,
using RNA-seq, real-time PCR, western blot, immunohistochemistry and transcriptome …