In the setting of liver cirrhosis (LC), profound hemostatic changes occur, which affect primary
hemostasis, coagulation, and fibrinolysis. They involve prohemorrhagic and prothrombotic
alterations at each of these steps. Patients with cirrhosis exhibit multifactorial
thrombocytopenia and in vitro thrombocytopathy, counterbalanced by increased von
Willebrand factor. The resultant shift is difficult to assess, but overall these changes probably
result in a rebalanced primary hemostasis. Concerning coagulation, the reduced activity of …