Diagnosis and management of cirrhosis and its complications: a review

EB Tapper, ND Parikh - Jama, 2023 - jamanetwork.com
Importance Cirrhosis affects approximately 2.2 million adults in the US. From 2010 to 2021,
the annual age-adjusted mortality of cirrhosis increased from 14.9 per 100 000 to 21.9 per
100 000 people. Observations The most common causes of cirrhosis in the US, which can
overlap, include alcohol use disorder (approximately 45% of all cases of cirrhosis),
nonalcoholic fatty liver disease (26%), and hepatitis C (41%). Patients with cirrhosis
experience symptoms including muscle cramps (approximately 64% prevalence), pruritus …