The role of the IL-8 signaling pathway in the infiltration of granulocytes into the livers of patients with alcoholic hepatitis
SW French, AS Mendoza, N Afifiyan, B Tillman… - Experimental and …, 2017 - Elsevier
Background and aim IL-8 (CXL motif chemokine ligase 8) and CXCR2 (CXC-motif
chemokine receptor 2) are up regulated in alcoholic hepatitis (AH) liver biopsies. One of the
consequences is the attraction and chemotactic neutrophilic infiltrate seen at the AH stage of
alcoholic liver disease. Materials and methods Human formalin-fixed, paraffin-embedded
(FFPE) liver biopsies from patients who have AH were studied by (2.1) RNA
sequencing,(2.2) PCR and (2.3) semi quantitation of specific proteins in biopsy sections …
chemokine receptor 2) are up regulated in alcoholic hepatitis (AH) liver biopsies. One of the
consequences is the attraction and chemotactic neutrophilic infiltrate seen at the AH stage of
alcoholic liver disease. Materials and methods Human formalin-fixed, paraffin-embedded
(FFPE) liver biopsies from patients who have AH were studied by (2.1) RNA
sequencing,(2.2) PCR and (2.3) semi quantitation of specific proteins in biopsy sections …