Mapping the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression
A Guillot, M Winkler, MS Afonso, A Aggarwal… - Hepatology, 2023 - journals.lww.com
Conclusions: Loss of hepatocytes and increased ductular reaction are tightly associated with
monocyte-derived macrophage accumulation and represent the most prominent common
immunological feature revealing the progression of NAFLD, primary sclerosing cholangitis,
primary biliary cholangitis, and alcoholic hepatitis, suggesting IBA1+ CD163 low
macrophages are key pathogenic drivers of human liver disease progression across diverse
etiologies.
monocyte-derived macrophage accumulation and represent the most prominent common
immunological feature revealing the progression of NAFLD, primary sclerosing cholangitis,
primary biliary cholangitis, and alcoholic hepatitis, suggesting IBA1+ CD163 low
macrophages are key pathogenic drivers of human liver disease progression across diverse
etiologies.