Background & Aims Ductular reaction expansion is associated with poor prognosis in
patients with advanced liver disease. However, the mechanisms promoting biliary cell
proliferation are largely unknown. Here, we identify neutrophils as drivers of biliary cell
proliferation and the defective wound-healing response. Methods The intrahepatic
localization of neutrophils was evaluated in patients with chronic liver disease. Neutrophil
dynamics were analyzed by intravital microscopy and neutrophil-labeling assays in DDC …