Long non-coding RNA ACTA2-AS1 promotes ductular reaction by interacting with the p300/ELK1 complex
A Navarro-Corcuera, TS Sehrawat, N Jalan-Sakrikar… - Journal of …, 2022 - Elsevier
Background & Aims Biliary disease is associated with a proliferative/fibrogenic ductular
reaction (DR). p300 is an epigenetic regulator that acetylates lysine 27 on histone 3
(H3K27ac) and is activated during fibrosis. Long non-coding RNAs (lncRNAs) are aberrantly
expressed in cholangiopathies, but little is known about how they recruit epigenetic
complexes and regulate DR. We investigated epigenetic complexes, including transcription
factors (TFs) and lncRNAs, contributing to p300-mediated transcription during fibrosis …
reaction (DR). p300 is an epigenetic regulator that acetylates lysine 27 on histone 3
(H3K27ac) and is activated during fibrosis. Long non-coding RNAs (lncRNAs) are aberrantly
expressed in cholangiopathies, but little is known about how they recruit epigenetic
complexes and regulate DR. We investigated epigenetic complexes, including transcription
factors (TFs) and lncRNAs, contributing to p300-mediated transcription during fibrosis …