Activation of cholangiocyte mTORC1 drives alcohol-induced ductular reaction
B Mackowiak, B Gao - Hepatology, 2023 - journals.lww.com
Alcohol consumption has increased over the COVID-19 pandemic, and this rise in alcohol
consumption has led to increases in alcohol-associated liver disease and alcohol-
associated hepatitis (AH) in particular.[ 1] The growing problem of AH has been exacerbated
by the lack of suitable therapeutics to reverse AH, with many patients requiring liver
transplants. The etiology of AH is complex, and current animal models of AH have not been
able to replicate certain hallmarks of severe AH that correlate with prognosis, including …
consumption has led to increases in alcohol-associated liver disease and alcohol-
associated hepatitis (AH) in particular.[ 1] The growing problem of AH has been exacerbated
by the lack of suitable therapeutics to reverse AH, with many patients requiring liver
transplants. The etiology of AH is complex, and current animal models of AH have not been
able to replicate certain hallmarks of severe AH that correlate with prognosis, including …